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What Is New In Bladder Cancer Research

By Luisa Sharpe


Bladder cancer research today is looking at new ways to detect the disease earlier as well as more effective and less invasive ways to treat it once it has been discovered. There are many trials and studies being done that will contribute vital information to what is already known by researchers.

The studies dealing with earlier detection use analyses of urine to detect the tumors through proteins common to the growth. There are three separate types of urine analyses that are showing promise. The BTA test looks for specific proteins that may signal a return of prior cancers. It is very accurate but can be influenced by other conditions.

Transitional cell cancers are the most common type of cancers detected by the NMP22 test. This test looks to the nucleus of proteins involved. Everyone has these proteins in their bodies but they are found in very small numbers. An elevated count of this protein serves as a red flag to doctors when they conduct this analysis.

A newer test than NMP22 has proven to be just as useful for detection of TCC. The Mcm5 is used in concert with the NMP22 and they can find TCC earlier than any other method. These three tests are not generally used unless other methods have proven ineffective.

Even with use of these tests, if they were commonly available, patients will still need to submit to an invasive procedure called the cystoscopy. This procedure entails a camera in the bladders of patients to find any tumors that may be present. Special chemicals are added to enhance the blood vessels that feed the tumors.

Treatment studies are also being conducted by many labs. One notable study is photodynamic therapy where your doctor puts the drug directly into bladders through using catheters and later fills them with saline solution. A special light is then directed at the lining of the organ and the light activates the drug. This process directly kills the cancerous cells, damages the blood vessels that feed the tumor and trigger your immune system to destroy the tumor.

Combination therapies are being tested and proving to be effective also. Radiotherapy and chemotherapy are used together to first shrink the tumor prior to considering surgery. Radiotherapy works to help stop the tumors from returning after treatment. Another step that is often added is to flood the affected area with oxygen because the cells die easier when they are flooded with oxygen.

Other therapies being researched are hyperthermia and chemotherapy used together to help stop the return of tumors in patients. Medication is placed into the patient and heated with a micro-wave probe to enhance its effectiveness. Another approach that is gaining popularity is biological therapies. This process uses natural body substances to fight this disease. The drugs being made from body substances are being tested in multiple trials to determine the extent of their effectiveness on several different cancers. They have proven effective in several studies and appear to have a promising outcome in many others. The scientists are also constantly developing new drugs for this condition. The new drugs must be thoroughly tested and proven prior to being used for treatment on humans.




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